By air, San Mateo is conveniently located near San Francisco International Airport SFO. Oakland OAK and San Jose SJC are alternative airports, though not preferable.
By rail, use CalTrain there are 3 CalTrain stations in San Mateo named San Mateo [downtown], Hayward Park, and Hillsdale or BART from Millbrae.
By car, US-101 and I-280 run through the city. It is also connected to the East Bay via the San Mateo-Hayward Bay Bridge.